Protopanaxadiol-Enriched Rice Exerted Antiadipogenic Activity during 3T3-L1 Differentiation and Anti-Inflammatory Activity in 3T3-L1 Adipocytes

Ginseng is a traditional medicine with health benefits for humans. Protopanaxadiol (PPD) an important bioactive compound found in ginseng. Transgenic rice containing PPD has been generated previously. In the present study, extracts of this transgenic were evaluated to assess their antiadipogenic and anti-inflammatory activities. During adipogenesis, cells treated seed extracts. The results revealed that concentrations tested study did not affect cell viability at 3 days post-treatment. However, significantly reduced accumulation lipids suppressed activation CCAAT/enhancer-binding protein α (C/EBPα) peroxisome proliferator-activated receptor γ (PPARγ), which turn inhibited expression adipogenesis-related mRNAs, such as adiponectin, PPARγ, C/EBPα, sterol regulatory element-binding 1, glucose transport member 4, fatty acid synthase. adipocytes, mRNA inflammation-related factors following LPS treatment. NF-κB p65 ERK 1/2 was extract-treated adipocytes. Moreover, treatment extract #8 markedly population G2/M phase. Collectively, these indicate may act obesity-reducing and/or -preventing agent.